Advancing Mental Health Care Through Sex- and Gender-Sensitive Treatments
Loss and regaining control in addictions
The main risk factors for mortality and morbidity worldwide are alcohol and tobacco consumption. While knowledge about individual factors that influence the initiation and maintenance of substance consums is increasing, there is still a lack of in-depth knowledge about modulatory factors and mechanisms that contribute to the loss and regaining of control over drug use. A better understanding of these factors and mechanisms will be critical to improving the treatment of substance use disorders (SUDs).The goal of our research consortium in TRR265 is to identify the trajectories of loss and regain of control over drug use, to investigate the underlying neurobiological and learning mechanisms, and to develop mechanism-based therapies. These goals should be achieved through 3 approaches: (I) the use of innovative mobile health tools to determine the influence of triggers, (II) in closely networked studies on humans and in animal models, the decisive mechanisms should be identified and mathematically modeled (III) based on this, interventions should be developed that specifically target these mechanisms in order to support regaining control over drug use.
TRAJECTORS
Longitudinal course of loss and regain of control in alcohol and drug use
project board
Andreas Heinz
Prof. Dr. med. Dr. phil. Andreas Heinz
Spokesman Period 1 TRR 265, Director of the Clinic for Psychiatry and Psychotherapy, Charité - Universitätsmedizin Berlin
Falk Kiefer
Deputy Spokesman TRR 265, Medical Director Clinic for Addictive Behavior and Addiction Medicine, ZI Mannheim
Michael Smolka
Deputy spokesman TRR 265, head of the research area systemic neurosciences, TU Dresden
Heike Tost
Prof. Dr. med. Dr. phil. Heike Tost
Deputy spokeswoman TRR 265, Dipl.-Psych., doctor, head of the working group Systemic Neurosciences in Psychiatry (SNiP), ZI Mannheim
Rainer Spanagel
Spokesman Period 2 TRR265, 2nd funding period. Scientific Director of the Institute for Psychopharmacology, ZI Mannheim
Steering committee
Spokesperson: Prof. Dr. rer. nat. Rainer Spanagel
Deputy Spokesperson: Prof. Dr. med. Dr. phil. Heike Tost
Deputy Spokesperson: Prof. Dr. med. Dr. phil. Andreas Heinz
Deputy Spokesperson: Prof. Dr. med. Michael Smolka
Young Scientist Representative: Prof. Dr. med. Shuyan Liu
Other members: Prof. Dr. rer. nat. Tanja Endrass
Other members: Prof. Dr. rer. nat. Christian Beste
Other members: Prof. Dr. med. Falk Kiefer
Other members: Prof. Dr. med. Dr. phil. Michael Rapp
figuresThe losing and regaining control over drug intake (ReCoDe) TRR 265 framework is divided into three research domains. Research Domain A relates to trajectories of alcohol and drug use; Research Domain B relates to mechanisms (eg cue reactivity) on different system levels (behavioural, neural, and molecular); and research Domain C focuses on the modification of mechanisms (eg, by increasing cognitive control via physical activity or neurofeedback).